Diffusion Kurtosis Imaging: A Possible MRI Biomarker for AD Diagnosis?
نویسندگان
چکیده
The purpose of this explorative study was to investigate whether diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) parameter changes are reliable measures of white matter integrity changes in Alzheimer's disease (AD) patients using a whole brain voxel-based analysis (VBA). Therefore, age- and gender-matched patients with mild cognitive impairment (MCI) due to AD (n = 18), dementia due to AD (n = 19), and age-matched cognitively healthy controls (n = 14) were prospectively included. The magnetic resonance imaging protocol included routine structural brain imaging and DKI. Datasets were transformed to a population-specific atlas space. Groups were compared using VBA. Differences in diffusion and mean kurtosis measures between MCI and AD patients and controls were shown, and were mainly found in the splenium of the corpus callosum and the corona radiata. Hence, DTI and DKI parameter changes are suggestive of white matter changes in AD.
منابع مشابه
Title Reconstructing diffusion kurtosis tensors from sparse noisymeasurements
Diffusion kurtosis imaging (DKI) is a recent MRI based method that can quantify deviation from Gaussian behavior using a kurtosis tensor. DKI has potential value for the assessment of neurologic diseases. Existing techniques for diffusion kurtosis imaging typically need to capture hundreds of MRI images, which is not clinically feasible on human subjects. In this paper, we develop robust denois...
متن کاملDiffusion Tensor Imaging
AD Axial diffusivity ADC Apparent diffusion coefficient ADHD Attention deficit hyperactivity disorder BET Brain extraction tool CSF Cerebrospinal fluid DKI Diffusion kurtosis imaging DTI Diffusion tensor imaging DWI Diffusion-weighted imaging FA Fractional anisotropy MD Trace, mean diffusivity MRI Magnetic resonance imaging RD Radial diffusivity ROI Region of interest TBSS Tract-based spatial s...
متن کاملDynamic Contrast Magnetic Resonance Imaging (DCE-MRI) and Diffusion Weighted MR Imaging (DWI) for Differentiation between Benign and Malignant Salivary Gland Tumors
Background: Salivary gland tumors form nearly 3% of head and neck tumors. Due to their large histological variety and vicinity to facial nerves, pre-operative diagnosis and differentiation of benign and malignant parotid tumors are a major challenge for radiologists. Objective: The majority of these tumors are benign; however, sometimes they tend to transform into a malignant form. Functional M...
متن کاملEvaluation of the relationship between axon injury and clinical symptoms in patients with multiple sclerosis using diffusion tensor MRI imaging
Background: Magnetic resonance imaging (MRI) is a non-invasive imaging technology that shows detailed anatomical and pathological images. It is often used for disease detection, diagnosis, and treatment monitoring, in particular with neurodegenerative diseases, such as Multiple sclerosis (MS), Alzheimer's and amyotrophic lateral sclerosis. However, conventional MRI provides only qualitative inf...
متن کاملStratification of heterogeneous diffusion MRI ischemic lesion with kurtosis imaging: evaluation of mean diffusion and kurtosis MRI mismatch in an animal model of transient focal ischemia.
BACKGROUND AND PURPOSE Ischemic tissue damage is heterogeneous, resulting in complex patterns in the widely used diffusion-weighted MRI. Our study examined the spatiotemporal characteristics of diffusion kurtosis imaging in an animal model of transient middle cerebral artery occlusion. METHODS Adult male Wistar rats (N=18) were subjected to 90 minutes middle cerebral artery occlusion. Multipa...
متن کامل